Study shows few serious problems among smallpox vaccinees

first_imgDec 14, 2005 (CIDRAP News) – Exactly 100 of about 38,000 civilians who received smallpox shots in a federal program in 2003 suffered serious adverse events afterward, signaling that the program successfully screened out most people at risk for complications, according to a recent report.The safety monitoring system “achieved its goal of safe administration of smallpox vaccine among a limited number of DHHS [Department of Health and Human Services] volunteers through successful exclusion of at-risk individuals and rapid detection of unexpected adverse events,” says the report, published in the Dec 7 Journal of the American Medical Association.The authors, with the Centers for Disease Control and Prevention (CDC), analyzed adverse events reported as a result of the smallpox vaccination program from January through October of 2003. HHS launched the program for healthcare and emergency response workers out of concern about the possibility of a terrorist release of smallpox virus. The report’s first author is Christine G. Casey, MD, of the CDC’s National Immunization Program.Authorities originally hoped to vaccinate as many as 500,000 health workers, but only 37,901 received shots by the end of October 2003. Hospital and public health workers constituted 95% of those, with law enforcement and firefighters making up most of the rest, the report says. Most of the vaccinees (64%) were women, and more than 75% of them were between 40 and 64 years old and had received a smallpox shot before.The Vaccine Adverse Event Reporting System (VAERS) received 822 adverse-event reports related to the vaccinations, the report says. Of these, 100 were classified as serious events, for a rate of 26.4 per 10,000 vaccinees.Of the 100 serious events, 85 involved hospitalization or prolongation of hospitalization. Two people suffered permanent disability, and 10 experienced a life-threatening illness. The serious events included 21 classified as myopericarditis and 10 classified as ischemic events that were not expected on the basis of patient histories. Those 10 included six myocardial infarctions, two of which were fatal, and four cases of new or increased angina. Two cases of dilated cardiomyopathy occurring 2 to 3 months after vaccination were also reported.As a result of cardiac adverse events in both civilian and military smallpox vaccinees, the CDC issued a Health Alert Notice on Mar 26, 2003, that described the events and recommended deferring vaccination for at-risk people. None of the 10 ischemic cardiac events in vaccinees occurred after the alert notice triggered cardiac screening of potential vacccinees, the report says.The authors note that US military personnel recently vaccinated against smallpox have had a significantly increased rate of myocarditis, compared with unvaccinated military members. However, the report says the rate of ischemic cardiac events in civilian vaccinees does not appear to exceed the rate in a comparable unvaccinated population.”Whether smallpox vaccination is causally associated with ischemic events remains uncertain,” the authors write.Two cases of generalized vaccinia and one case of postvaccinial encephalitis were reported in the program. But there were no cases of transmission of vaccinia (the vaccine virus) to others and no severe reactions requiring treatment with vaccinia immune globulin.Among the 722 “nonserious” adverse events reported, the most common signs and symptoms were fever, 18.9%; rash, 18.4%; pain, 16.0%; headache, 15.2%; fatigue, 13.5%; and pruritus, 13.4%. Compared with those reporting nonserious events, people reporting serious events were more likely to be older than 40 (81% versus 64%).People who had been vaccinated previously were slightly overrepresented among the vaccinees with serious adverse events, the authors found. They say this is not surprising, since the revaccinees were older than the primary vaccinees and may have had a higher risk of adverse events because of age-related underlying chronic disease.The rates of expected, preventable, and noncardiac adverse events in the civilian vaccinees were about the same as rates in the much larger military vaccination program, the authors found.Casey CG, Iskander JK, Roper MH, et al. Adverse events associated with smallpox vaccination in the United States, January-October 2003. JAMA 2005 Dec 7;294(21):2734-43 [Abstract]See also:Safety summary for Department of Defense smallpox vaccination programhttp://www.smallpox.mil/event/SPSafetySum.asplast_img read more

NASCAR’s ‘Cat in the Hat,’ Jack Roush, to become the ‘Cat in the Hall (of Fame)’

first_imgThat staying power has been crucial and well-praised.  Even at age 76, he is a staple in the garage and on the pit box. This season he will field Fords in the Monster Energy NASCAR Cup Series for Ricky Stenhouse Jr. and Ryan Newman. The expectations remain the same through all these decades. Succeed and lead. It’s a theme to which Roush has stayed true.”I can’t believe I’ve been the recipient of so much great schooling and great support to accomplish all the things I dreamed of and some of the things I never dreamed of,” Roush said.Holly Cain writes for the NASCAR Wire Service. For so many, Roush’s official new title, “NASCAR Hall of Famer,” was inevitable and necessary. Not only did the former Ford Motor Company engineer field championship cars at every level of NASCAR competition, he is also considered one of the sport’s most important innovators.From helping to create the “roof flaps” installed to keep cars from easily launching off the ground to running championship race teams across all of NASCAR’s primary series, the 76-year old Roush has been a staple of the sport and now he will be ceremoniously celebrated as a member of the NASCAR Hall of Fame Class of 2019.  He joins team owner Roger Penske, the late Cup champion Alan Kulwicki, the late Davey Allison and four-time Cup champion Jeff Gordon in this year’s highly regarded Hall of Fame class.”It’s awesome and on the back of giants,” Roush said after his name was announced.HALL OF FAME: Fellow owner Roger Penske joining Roush in Hall”Who would have thought it,” he added. “Thirty-one years ago when we first got started, I was just hoping to stay in the sport a little while.”I cannot imagine my name is with the 45 people already inducted and all the things they accomplished. And of course with Mark [Martin] being in there, Roger Penske being in there and my Wood Brothers friends being in there. It’s rarefied air and I have to take a while to think about it and all it means to me. But it’s certainly taking my breath.”Roush’s former and longtime Cup series driver Mark Martin — a 2017 NASCAR Hall of Fame inductee himself – wasn’t surprised about his longtime friend and team owner earning the sport’s greatest honor. A Hall of Fame voter, Martin was among the very first to congratulate Roush and remind everyone of the important contributions his friend has made to NASCAR and racing in general.”It means everything in the world to me,” Martin said. “I’m so happy with this class and so happy for Jack.”Jack Roush did so much for so many people, not just for me, in giving me my second chance when no one else would but so many other great race car drivers and all the other people in the shops he mentored, encouraged and gave them all the tools that were it not for Jack Roush wouldn’t have had the opportunity to succeed. … Just the kind of person Jack is and has been and what he’s meant to all those people we celebrate today because of him.”Roush joked that he was just hoping “to stay in the sport awhile” when he initially became involved in NASCAR 31 years ago after a celebrated career at Ford Motor Company — an association still so important to Roush today that he has only ever fielded Fords in competition.His first full-time Cup season was 1988 when he fielded a Ford for Martin. The team’s first victory came the following year at Rockingham, N.C. Martin answered that maiden win with three more the following season and finishing runner-up to the late Dale Earnhardt by 26 points in the Cup championship.MORE: Ryan Newman to drive No. 6 Roush car in 2019Including that first victory at Rockingham, Roush has 137 total wins at the Cup level – second only to fellow Hall of Famer Rick Hendrick. He led his team to back-to-back Cup titles – for Matt Kenseth in 2003 and then Kurt Busch in 2004. And in addition to the big trophies, he finished championship runner-up another eight times – including four seasons with Martin.Roush teams earned 137 wins in the Xfinity Series and five championship trophies, including current Roush Monster Energy NASCAR Cup Series driver Ricky Stenhouse Jr.’s back-to-back titles in 2011-12. His last came with driver Chris Buescher in 2015.His teams have 50 NASCAR Gander Outdoors Truck Series wins and the 2000 series championship with driver Greg Biffle. Twice more Roush truck teams finished runner-up with Biffle in 1999 and Kurt Busch in 2001.In all, Roush has an amazing 324 NASCAR premier series victories – most all time. Fellow Hall of Famer Rick Hendrick has 301.And yet if you were to ask Roush what he considers the most important victory of all, he undoubtedly will say his very first.”I’m most proud of winning that first race with Mark in 1989 in Rockingham, because what it meant to me was I could find a sponsor to keep going. And what it meant to Mark, the team would be solid and keep putting cars under him,” Roush explained. “There was some doubt in both our minds if we were going to be able to turn the corner and both stay.” This is the third in a five-part series of features highlighting the NASCAR Hall of Fame Class of 2019: Davey Allison, Jeff Gordon, Alan Kulwicki, Roger Penske and Jack Roush. The class will be officially enshrined Feb. 1 at the Charlotte (N.C.) Convention Center, broadcast live at 8 p.m. ET on NBCSN, MRN and SiriusXM NASCAR Radio.DAYTONA BEACH, Fla. — His name is spoken in automotive rarefied air. And as a NASCAR team owner, an engineer, an innovator and all-around highly respected member of the sport, Jack Roush will be formally inducted into the NASCAR Hall of Fame on Feb. 1.last_img read more